Pernicious anemia pa is megaloblastic anemia resulting from a deficiency of cobalamin vitamin b12 which in turn is caused by a lack of intrinsic factor if intrinsic factor is a glycoprotein that binds cobalamin and thereby enables its absorption in the terminal ileum pernicious anemia is often described as an autoimmune disorder due to the findings of gastric.

Pernicious anemia cobalamin cbl is freed from meat in the acidic milieu of the stomach where it binds r factors in competition with intrinsic factor if cbl is.

Other symptoms of pernicious anemia can include the following 1 pale skin weakness of the arms and legs tingling or prickling of the skin shortness of the breath dizziness racing heartbeat abdominal bloating diarrhea weight loss swelling of the extremities darkened skin poor balance forgetfulness.